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HIV is a virus that attacks the immune system, particularly infection-fighting CD4 cells. People may have no symptoms for years, so testing is essential for diagnosis. HIV and AIDS are not the same: AIDS is the most advanced stage of HIV infection. Effective antiretroviral therapy, or ART, suppresses the virus and helps protect immune function, but it does not remove HIV from the body. Ongoing treatment and regular care remain important even when someone feels well.

A clinician experienced in HIV care reviews test results, medical history, other infections, medicines and individual needs before selecting treatment. Follow-up includes viral load testing, assessment of immune recovery and checks for treatment effects and other health conditions. Care also supports mental wellbeing, sexual health and reproductive planning. If there may have been a recent exposure to HIV, seek urgent local assessment for post-exposure prevention rather than waiting for a routine appointment or travel.

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Testing and the first assessment

HIV cannot be diagnosed from symptoms or appearance. Testing may use antigen, antibody or viral tests, depending on timing and circumstances. A reactive screening result requires confirmation through the appropriate testing pathway. An early negative result may need repeating because tests have different window periods. Tell the clinician when a possible exposure occurred.

After diagnosis, an HIV specialist reviews viral load, CD4 count, resistance testing, other medicines and relevant kidney or liver conditions. Screening for tuberculosis, viral hepatitis and other infections is tailored to the situation. Pregnancy, breastfeeding and childhood require specific expert guidance rather than a standard adult plan.

Antiretroviral treatment and monitoring

ART is recommended for people with HIV and should be started promptly following clinical assessment. Certain active infections, such as cryptococcal meningitis, require a specialist plan for timing. The regimen is individualised, including consideration of interactions, resistance, pregnancy and other conditions. Effective treatment suppresses HIV rather than curing it. Do not stop or switch treatment without discussing a safe plan with the HIV team.

Regular viral load tests show whether treatment is controlling the virus. CD4 testing helps assess immune function and the need for measures against opportunistic infections. Discuss side effects, missed doses or difficulties obtaining medicines early. Planning transfers of care or travel should protect continuity of medication and monitoring.

Prevention and living with HIV

A person who takes effective ART and achieves and maintains an undetectable viral load does not transmit HIV through sex: this is called U=U. Ongoing treatment and monitoring are essential. This statement does not mean HIV is cured, prevent other sexually transmitted infections or apply automatically to breastfeeding or shared injection equipment.

Care also includes vaccinations where appropriate, other infection screening, cardiovascular health, mental health and support with disclosure decisions. HIV is not transmitted by ordinary social contact, sharing meals or hugging. Confidential, nonjudgmental support can help people remain engaged in care.

Frequently asked questions

Does HIV always progress to AIDS?

No. Effective ongoing ART can prevent progression. A positive HIV test does not itself mean that a person has AIDS.

Can treatment be stopped when viral load is undetectable?

No. HIV remains in the body and usually rebounds if effective treatment stops. Discuss any interruption or medication shortage with the treating team promptly.

What if I may have been exposed recently?

Seek urgent local care immediately. Post-exposure prophylaxis is time-critical and should begin within 72 hours when indicated; do not wait for symptoms or travel.

Which symptoms need urgent help?

Severe breathlessness, confusion, a new severe headache or rapidly worsening illness needs urgent local assessment, especially with advanced immune suppression.

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Immunology: treatment and diagnostics abroad

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